In recent decades, medicine has undergone a fundamental change. The computer has entered medical practices and clinics. X-ray and ultrasound images are now digitally recorded. Today, MRI and CT scanners deliver three-dimensional images and videos of the inside of the body. The Fraunhofer Institute for Medical Image Computing MEVIS in Bremen has contributed significantly to the field and developed a range of innovative software methods. On September 14, the Institute celebrated its twentieth anniversary with an official ceremony in Bremen’s City Hall. Founded as a nonprofit Ltd in 1995, it became part of the Fraunhofer-Gesellschaft in 2009. Today, it is one of the leading institutes for computer support in image-based medicine worldwide.